CCCP experimental evolution of Escherichia coli K-12 selects for mutations that increase EmrA activity or that downregulate other PMF-driven drug efflux pumps
Jessie M. Griffith, Preston J. Basting, Katarina M. Bischof, Erintrude P. Wrona, Karina S. Kunka, Anna C. Tancredi, Jeremy P. Moore, Miriam R. L. Hyman, Joan L. Slonczewski
This paper shows that experimental evolution of E. coli under CCCP selects for mutations increasing EmrA activity or reducing other PMF-driven efflux pumps, enhancing CCCP resistance.
bioRxiv · Aug 16, 2018 · PreprintMicrobiology