Impact of protein degradation and cell growth on mammalian proteomes
Andrew Leduc, Shanshan Zheng, Purvi Saxena, Nikolai Slavov
The paper quantifies how growth-dependent dilution and protein degradation affect protein abundance across human B-cells, tissues, and proteoforms, showing dilution explains 40% of abundance changes.
bioRxiv · Feb 10, 2025 · PreprintBiochemistry