Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: potential implications for SARS-CoV-2 infection of vascular endothelial cells.
Q. K. Toe, T. Issitt, A. Mahomed, I. Panselinas, F. Almaghlouth, A. Burke-Gaffney, S. J. Wort, G. J. Quinlan
This study shows that human pulmonary artery endothelial cells increase ACE2 expression in response to IL-6 and hepcidin, which are elevated in severe COVID-19 and high-risk populations.
bioRxiv · Apr 8, 2021 · PreprintCell Biology