Targeting ALCAT1 Ameliorates Cardiomyopathy in Barth Syndrome
Jun Zhang, Qianqian Ye, Xi Fang, Wendong Huang, Yuguang Shi
This study shows that targeting ALCAT1 improves cardiac function in Barth syndrome by restoring mitochondrial quality control through phosphatidylinositol signaling and lysosomal function, without correcting cardiolipin abnormalities.
bioRxiv · Sep 28, 2026 · PreprintCell Biology