TopoLa: A Universal Framework to Enhance Cell Representations for Single-cell and Spatial Omics through Topology-encoded Latent Hyperbolic Geometry
Kai Zheng, Shaokai Wang, Yunpei Xu, Qiming Lei, Qichang Zhao, Xiao Peng Liang, Qilong Feng, Yaohang Li, Min Li, Jinhui Xu, Jianxin Wang
TopoLa enhances cell representations in single-cell and spatial omics by using topology-encoded latent hyperbolic geometry, improving performance across multiple tasks.
bioRxiv · Jul 23, 2025 · PreprintBioinformatics