A bifunctional imprinted lncRNA scaffolds NuRD-HDAC1 to couple cis-activation of Dio3 with trans-repression of the osteoblast chromatin landscape
Yuechuan Chen, Benjamin Wildman, Mohammad Rehan, Snehasis Mishra, Shazia Khan, Lubana H. Afreen, Quamarul Hassan
The paper shows Dio3os scaffolds NuRD-HDAC1 to activate Dio3 in cis and repress thyroid-hormone-responsive osteogenic genes in trans.
bioRxiv · Apr 14, 2025 · PreprintMolecular Biology