Multi-omic gene regulatory networks informed by 3D chromatin architecture reveal insights into hematopoietic stem cell ageing
Quinn Stacpoole, Nadia Iannarella, Timothy M. Johanson, Hannah D. Coughlan, Rhys S. Allan
This study integrates 3D chromatin architecture with gene expression and accessibility data to identify regulatory changes in aged HSCs and propose targets for reprogramming.
bioRxiv · Apr 23, 2026 · PreprintImmunology