Hannah D. Coughlan

This study shows that PU.1 regulates granulocyte maturation by controlling transcriptional programs and 3D chromatin architecture through its binding sites.

This study integrates 3D chromatin architecture with gene expression and accessibility data to identify regulatory changes in aged HSCs and propose targets for reprogramming.

This study shows that Suv39h enzymes are essential for organizing euchromatic regions and maintaining gene transcription by tethering H3K9me3 domains to the nuclear lamina.

The paper identifies a novel Myc enhancer activated in B cells shortly after activation but finds it is not essential for Myc expression or cell proliferation.

This study develops a synthetic de-methylating module to reactivate stably silenced genes by combining TET1's demethylating activity with transcriptional activators.

The paper shows genome reorganization occurs in discrete waves before DNA replication and mitosis, controlling B cell differentiation into plasma cells.

This study examines how T cell activation alters chromatin structure and gene expression, identifying changes in chromatin interactions and domain organization.

The paper uses high-resolution genome-wide chromosome conformation capture to analyze transchromosomal interactions in immune cells and finds no evidence of gene regulatory transchromosomal interactions.