Identifying Cancer-Relevant Mutations in the DLC START Domain using Evolutionary and Structure-Function Analyses
A. S. Holub, R. A. Bouley, R. C. Petreaca, A. Y. Husbands
The paper identifies cancer-relevant mutations in the DLC START domain using evolutionary and structure-function analyses, finding conserved residues overrepresented in cancer cells and critical for START domain stability.
bioRxiv · Sep 20, 2020Cancer Biology