Author

A. S. Holub

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Y. Husbands· 2 shared A. Feller· 1 shared C. E. Dresden· 1 shared M. C. P. Timmermans· 1 shared R. A. Bouley· 1 shared R. C. Petreaca· 1 shared T. Ha· 1 shared V. Aggarwal· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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2 shared papersPlant Biology

A. Y. Husbands

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2 papers

Recent·Most cited

The START domain potentiates HD-ZIPIII transcriptional activity

A. Y. Husbands, A. Feller, V. Aggarwal, C. E. Dresden, A. S. Holub, T. Ha, M. C. P. Timmermans

This study identifies the START domain's role in enhancing HD-ZIPIII transcriptional activity through homodimerization and ligand-induced conformational changes.

bioRxiv · Oct 8, 2022Plant Biology

Identifying Cancer-Relevant Mutations in the DLC START Domain using Evolutionary and Structure-Function Analyses

A. S. Holub, R. A. Bouley, R. C. Petreaca, A. Y. Husbands

The paper identifies cancer-relevant mutations in the DLC START domain using evolutionary and structure-function analyses, finding conserved residues overrepresented in cancer cells and critical for START domain stability.

bioRxiv · Sep 20, 2020Cancer Biology