R. Arnaout

Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires

This study compares antibody and TCR repertoires in SARS-CoV-2 infectees, vaccinees, and controls to predict neutralizing antibody titers and identifies subtle differences in adaptive immune responses.

Repertoire-Scale Measures of Antigen Binding

The paper introduces a framework to assess immune repertoires based on epitope-binding properties of antibodies and TCRs, showing its application in distinguishing immune responses and stratifying cohorts.

ct2vl: Converting Ct Values to Viral Loads for SARS-CoV-2 RT-qPCR Test Results

The paper introduces ct2vl, a Python package that converts RT-qPCR Ct values to viral loads for SARS-CoV-2 tests, enabling quantitative analysis of test results.

Private Antibody Repertoires Are Public

The paper demonstrates overwhelming functional overlap between antibody repertoires from 20 individuals, showing shared antigen-binding capacities that decline with age.

SARS-CoV2 Testing: The Limit of Detection Matters

This study evaluates how the limit of detection (LoD) of SARS-CoV-2 assays affects false negative rates using 27,500 test results, finding a 13% increase in false negatives per 10-fold LoD increase.

Repertoire-Based Diagnostics Using Statistical Biophysics

This paper introduces a descriptor-based MaxEnt model for classifying immune repertoires, achieving high accuracy in influenza vaccination status classification with limited samples.

Immunological Diversity with Similarity

The paper develops a framework for functional immunological diversity using binding data and applies it to reveal patterns in immunological memory and aging, showing functional diversity captures more information than raw diversity.