Author

J. E. Kirby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. B. Green· 2 shared K. A. Truelson· 2 shared K. E. Zulauf· 2 shared K. P. Smith· 2 shared L. Chiaraviglio· 2 shared S. Rodriguez· 2 shared T. Brennan-Krohn· 2 shared Y.-S. Kang· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

A. B. Green

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Versatile Nanoluciferase Reporter Reveals Structural Properties Associated With a Highly Efficient, N-Terminal Legionella pneumophila type IV Secretion Translocation Signal

Y.-S. Kang, J. E. Kirby

This paper develops a nanoluciferase reporter system to study T4SS translocation, finding that NLuc itself is efficiently translocated by L. pneumophila T4SS and identifies an N-terminal alpha helix domain as critical for translocation.

bioRxiv · May 25, 2022Microbiology

Transcriptomics reveals how minocycline-colistin synergy overcomes antibiotic resistance in multidrug-resistant Klebsiella pneumoniae

T. Brennan-Krohn, A. Grote, S. Rodriguez, J. E. Kirby, A. M. Earl

This paper identifies a synergistic antibiotic combination effective against multidrug-resistant Klebsiella pneumoniae and characterizes its transcriptional mechanisms.

Antimicrobial Agents and Chemotherapy · Mar 15, 2022Peer-reviewedMicrobiology

Profiling the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales: a historic scaffold with a novel mechanism of action

K. P. Smith, Y.-S. Kang, A. B. Green, M. G. Dowgiallo, B. C. Miller, L. Chiaraviglio, K. A. Truelson, K. E. Zulauf, S. Rodriguez, R. Manetsch, J. E. Kirby

This paper evaluates the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales, identifying its potent activity and novel mechanism of action involving 16S rRNA helix 34.

bioRxiv · Jun 14, 2021 · PreprintMicrobiology

Amotosalen is a bacterial multidrug efflux pump substrate potentially affecting its pathogen inactivation activity

A. B. Green, K. E. Zulauf, K. A. Truelson, L. Chiaraviglio, M. Cui, Z. Zhang, M. P. Ware, W. A. Flegel, R. L. Haspel, E. W. Yu, J. E. Kirby

The paper investigates whether amotosalen, a psoralen used in pathogen inactivation, is a substrate for bacterial multidrug efflux pumps, finding it is pumped out by RND systems in E. coli and Acinetobacter baumannii, potentially reducing its inactivation efficacy against multidrug-resistant pathogens.

bioRxiv · Mar 15, 2021 · PreprintMicrobiology

Synergistic Activity of Minocycline and Rifampin in Combination with Antifungal Drugs against Candida auris

T. Brennan-Krohn, L. Friar, S. Ditelberg, J. E. Kirby

The paper evaluates synergistic activity of minocycline and rifampin with antifungal drugs against Candida auris isolates using checkerboard and time-kill methods.

bioRxiv · Feb 23, 2021 · PreprintMicrobiology

SARS-CoV2 Testing: The Limit of Detection Matters

R. Arnaout, R. Lee, G. R. Lee, C. Callahan, C. F. Yen, K. P. Smith, R. Arora, J. E. Kirby

This study evaluates how the limit of detection (LoD) of SARS-CoV-2 assays affects false negative rates using 27,500 test results, finding a 13% increase in false negatives per 10-fold LoD increase.

bioRxiv · Jun 2, 2020 · PreprintMicrobiology