R. Blind

A novel heuristic of rigid docking scores positively correlates with full-length nuclear receptor LRH-1 regulation.

This paper introduces a novel docking score metric, ΔΔG, which correlates with full-length LRH-1 regulation by compounds in cell-based assays.

Bilirubin is a new ligand for nuclear receptor Liver Receptor Homolog-1.

This study identifies bilirubin as a direct ligand for LRH-1, showing it modulates LRH-1 activity and gene regulation in liver cells.

Multiple inositol phosphate species enhance stability of active mTOR

This study shows multiple inositol phosphate species enhance mTOR and mTORC1 kinase activity in vitro by stabilizing an active form of the kinase.