Identification of parallel and divergent optimization solutions for homologous metabolic enzymes
R. F. Standaert, R. J. Giannone, J. K. Michener
The paper identifies mutations improving enzyme activity in heterologous expression of 4-hydroxybenzoate monooxygenase homologs in E. coli, showing both common and specific mutations across homologs.
bioRxiv · Feb 5, 2018Bioengineering