Author

R. K. Murarka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:deep learning· 3 Research Focus:protein folding & dynamics· 3 Approach:mechanistic / dynamical model· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

M. K. Madhu· 3 shared K. Shewani· 2 shared A. Debroy· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 2 mutual co-author links

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3 shared papersBiophysics

M. K. Madhu

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3 papers

Recent·Most cited

Mechanistic Insights into G-protein Activation via Phosphorylation Mediated Non-Canonical Pathway

K. Shewani, M. K. Madhu, R. K. Murarka

This study identifies how RTK phosphorylations induce G-protein activation through structural changes and faster GDP release.

bioRxiv · Jan 15, 2024Biophysics

Biased Signaling in Mutated Variants of β2-Adrenergic Receptor: Insights from Molecular Dynamics Simulations

M. K. Madhu, K. Shewani, R. K. Murarka

This study uses molecular dynamics simulations to investigate how mutations in β2-adrenergic receptor cause biased signaling toward β-arrestin or G proteins.

bioRxiv · Sep 14, 2023 · PreprintBiophysics

Molecular insights into phosphorylation-induced allosteric conformational changes in β2-adrenergic receptor

M. K. Madhu, A. Debroy, R. K. Murarka

This study uses molecular dynamics simulations to investigate phosphorylation-induced conformational changes in β2-adrenergic receptor, revealing a new state that facilitates β-arrestin binding.

bioRxiv · Oct 1, 2021Biophysics