Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves
R. M. Adams, T. Mora, A. M. Walczak, J. B. Kinney
This paper introduces TiteSeq, a method to measure binding affinities of thousands of antibody variants, revealing structural insights and the role of secondary CDR loops in stability.
bioRxiv · Jan 10, 2016Biophysics