ImmunologybioRxiv
IRF4 haploinsufficiency in a family with Whipples disease
A. Guerin, G. Kerner, N. Marr…·J.-L. Casanova
This study identifies IRF4 haploinsufficiency as the genetic cause of Whipples disease in a family, showing age-dependent incomplete penetrance and chronic Tw carriage preceding disease onset.
DOI 10.7554/elife.32340