SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis
A. J. Njouendou, A. A. Z. Tiofack, R. N. Kenfack, S. N. Ananga, E. H. M. D. Bell, G. Simo, J. D. Hoheisel, J. T. Siveke, S. S. Lueong
The paper identifies SOX2 amplification as a driver of tumor aggressiveness by sustaining inflammation through the FOSL2/IL6 axis, leading to DNA damage and genome instability.
bioRxiv · Jun 9, 2022 · PreprintCancer Biology