Flexibility of Short-chain dehydrogenase is interconnected to its promiscuity for the reduction of multiple ketone intermediates
A. P. Shanbhag, S. Rajagopal, A. Ghatak, N. Katagihallimath, R. S., S. Datta
The paper uses machine learning to identify promiscuous SDRs based on physicochemical properties, showing a correlation between C-terminal structure, melting temperature, and catalytic efficiency.
bioRxiv · Jul 5, 2021Biochemistry