S. Rajagopal

ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins

The paper identifies novel GPCR interacting proteins independent of G proteins and β-arrestins using proximity labeling in cells lacking β-arrestin.

Tag attachment reduces the initiation of recruitment in the rock ant, Temnothorax rugatulus

This study shows that tracking tags reduce recruitment behavior in rock ants without affecting individual activity.

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

Subcellular localization of GPCR kinases differentially modulate biased signaling at CXCR3

The paper shows GRKs translocate to endosomes after CXCR3 activation, with ligand-specific GRK recruitment affecting biased signaling.

Single-Cell Analysis Identifies Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension

This study uses single-cell RNA sequencing to identify immune and smooth muscle cell populations in CTEPH thrombus, revealing inflammatory mechanisms and a potential therapeutic target.

Location bias contributes to functionally selective responses of biased CXCR3 agonists

The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.

Environment dependent benefits of inter-individual variation in honey bee recruitment

This study extends an agent-based model of honey bee foraging to show that response intensity, not probability, drives inter-individual variation in recruitment behavior, which benefits colony foraging efficiency under abundant food conditions.

Flexibility of Short-chain dehydrogenase is interconnected to its promiscuity for the reduction of multiple ketone intermediates

The paper uses machine learning to identify promiscuous SDRs based on physicochemical properties, showing a correlation between C-terminal structure, melting temperature, and catalytic efficiency.

Biased agonists of the chemokine receptor CXCR3 differentially drive formation of Gαi:β-arrestin complexes

The paper shows that biased agonists of CXCR3 differentially drive the formation of Gi:β-arrestin complexes, independent of G protein signaling or β-arrestin recruitment.

Maximization of non-nitrogenous metabolite production in E. coli using population systems biology

This paper develops a population systems biology algorithm to enhance non-nitrogenous metabolite production in E. coli by considering transcriptome diversity and introducing nitrogen-swap strategies.

Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors

The paper demonstrates that Gαi proteins can form complexes with β-arrestin, independent of their canonical G protein coupling, and these complexes can bind GPCRs and ERK.

Pathogen evasion of chemokine response through suppression of CXCL10

This paper identifies a mechanism by which Leishmania major evades the immune system by cleaving CXCL10, a chemokine critical for T-cell recruitment, and shows similar strategies are used by other pathogens.