Human adipose-derived mesenchymal stromal cells from face and abdomen undergo replicative senescence and loss of genetic integrity after long-term culture
P. B. Delben, H. D. Zomer, C. A. Silva, R. S. Gomes, F. R. Melo, P. Dillenburg-Pilla, A. G. Trentin
This study shows that human facial and abdominal adipose-derived mesenchymal stromal cells undergo replicative senescence and genetic instability after long-term culture, with facial cells showing fewer mitotic errors.
bioRxiv · Apr 16, 2021Cell Biology