A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress
Y. LIAO, C.-H. Chen, N. Shah, T. Xiao, A. Feit, M. Yang, C. Cai, S. Gao, P. Xue, Z. Liu, H. Xu, J. Lee, W. Li, S. Mei, R. S. Pierre, , K. Xu
This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.
bioRxiv · Sep 11, 2020 · PreprintCancer Biology