An epigenetic switch regulates the ontogeny of AXL positive/EGFR-TKI resistant cells by modulating miR-335 expression
R. Sordella, D. Pal, P. Safaric Tepes, T. Lindsted, I. Ibarra, A. Lujambio, V. Jimenez Sabinina, S. Senturk, M. Miller, N. Korimerla, J. Huang, L. Glassman, P. Lee, D. Zeltsman, K. Hyman, , G. Hannon
The paper identifies an epigenetic mechanism regulating AXL-positive/Erlotinib-resistant cells through miR-335 expression, suggesting combinatorial therapies for EGFR-mutated NSCLC.
bioRxiv · Jan 6, 2021Cancer Biology