The Helicobacter pylori Methylome is Acid-Responsive due to Regulation by the Two-Component System ArsRS and the Type I DNA Methyltransferase HsdM1 (HP0463)
E. H. Zimmerman, E. L. Ramsey, K. E. Hunter, S. M. Villadelgado, C. M. Phillips, R. T. Shipman, M. H. Forsyth
This study shows that Helicobacter pylori's methylome responds to acidity via the ArsRS two-component system and HsdM1, with differential methylation patterns affecting gene expression during acid stress.
bioRxiv · Sep 22, 2023 · PreprintMicrobiology