Loss of Hippo signaling causes transdifferentiation of neural retina between the optic fissure edges causing coloboma
Uma M Neelathi, Daniel Sanchez-Mendoza, Sydney Steele, Rachel M Aguda, Brian P. Brooks
The paper shows that loss of Hippo signaling components yap1 and wwtr1 causes transdifferentiation of neural retina at the optic fissure, leading to coloboma.
bioRxiv · Mar 17, 2026 · PreprintGenetics