Threonine Supplementation Reduces Methylglyoxal Overflow by Increasing Glycolysis Flux at the Payoff Phase: A Metabolic Modeling Analysis
Sandra Francis, Rahad Rehas, Yuttamol Muangkram, Niyas Rehman, Anoop Kumar G. Velikkakath, Shuhei Noda, Michihiro Araki
This study uses metabolic modeling to show that threonine supplementation reduces methylglyoxal overflow in E. coli by enhancing glycolytic flux, with limited effect under hypoxic conditions.
bioRxiv · Sep 18, 2026 · PreprintSystems Biology