Evaluating codon optimization strategies for mammalian glycoprotein production with an open-source expression vector
Chang Yang, Raina Soni, Sarah Visconti, Mina Abdollahi, Filmawit Belay, Anita Ghosh, Samuel W. Duvall, Curtis J. W. Walton, Rob Meijers, Haisun Zhu
The paper evaluates codon optimization strategies for mammalian glycoprotein production and finds that native codons are sufficient, while selective codon skewing can improve yields for some targets.
bioRxiv · Mar 20, 2026 · PreprintMolecular Biology