A simple approach for multiple observations improves power to detect genetic effects and genomic prediction accuracy.
Luke M. Evans, Christopher H. Arehart, Raine A Gibson, Grace I. Bowman, Christopher R. Gignoux
This paper shows that using the mean or median of multiple observations improves GWAS power and polygenic prediction accuracy by reducing phenotypic noise.
Human Genetics and Genomics Advances · Mar 7, 2026Peer-reviewedGenetic & Genomic Medicine