Tonya M. Brunetti

A Candida glabrata adhesin-like effector drives fitness and immunogenicity in the gut

This study identifies Awp11, an adhesin-like effector in Candida glabrata, as a key determinant of strain-dependent immunogenicity and gut colonization.

Siglec-F Protects Against Elastase-induced Lung Inflammation and Emphysema in Mice

This study shows that Siglec-F protects against elastase-induced lung inflammation and emphysema by regulating airspace macrophages in mice.

Modeling the genomic architecture of adiposity and anthropometrics across the lifespan

This study models the genomic architecture of adiposity and anthropometrics across the lifespan, identifying shared and distinct genetic factors and their associations with health outcomes.

Single-Cell Profiling Reveals Global Immune Responses during the Progression of Murine Epidermal Neoplasms

This study uses single-cell profiling to analyze immune cell changes in murine skin tumors, identifying macrophages as key regulators and highlighting immunosuppressive shifts during tumor progression.

Deep mutationally scanned (DMS) CHIKV E3/E2 virus library maps viral amino acid preferences and predicts viral escape mutants of neutralizing CHIKV antibodies

This study uses deep mutational scanning of CHIKV E3/E2 glycoprotein mutants to identify amino acid preferences and predict viral escape mutants against neutralizing antibodies.

Characterizing substructure via mixture modeling in large-scale genetic summary statistics

Summix2 uses mixture modeling to estimate and adjust for substructure in genetic summary data, improving the robustness and equity of research using diverse datasets.

IL-27 Stablizes Myc-Mediated Transcription In Memory-Fated, Vaccine-Elicited CD8+ T Cells

Subunit vaccines induce CD8+ T cells with memory fate characteristics that maintain proliferative capacity via IL-27 receptor signaling during expansion.

Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils

This study shows vimentin regulates neutrophil mitochondrial ROS production and inflammatory responses by modulating mitochondrial function and ROS levels.

Building a Vertically-Integrated Genomic Learning Health System: The Colorado Center for Personalized Medicine Biobank

The paper describes the CCPM Biobank, a dual-purpose genomic resource linking health records and genomic data to support research and clinical applications.

SAIGE-BRUSH: an efficient, user-friendly and low cost cloud implementation for genome-wide association studies

SAIGE-BRUSH provides a cloud-based, user-friendly GWAS tool with parallelization and data management features, enabling non-experts to perform genome-wide association studies efficiently.