Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
Zhili Zheng, Shouye Liu, Julia Sidorenko, Ying Wang, Tian Lin, Loïc Yengo, Patrick Turley, Alireza Ani, Rujia Wang, Ilja Maria Nolte, Harold Snieder, LifeLines Cohort Study, Raul Aguirre-Gamboa, Patrick Deelen, Lude Franke, , Jian Zeng
This paper introduces SBayesRC, a method that improves polygenic prediction of complex traits by integrating GWAS summary statistics with functional genomic annotations, showing significant accuracy gains across ancestries.
Nature Genetics · Apr 30, 2024Peer-reviewedGenetics