GeneticsNature GeneticsPeer-reviewed
Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
Zhili Zheng, Shouye Liu, Julia Sidorenko…·Jian Zeng
This paper introduces SBayesRC, a method that improves polygenic prediction of complex traits by integrating GWAS summary statistics with functional genomic annotations, showing significant accuracy gains across ancestries.
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