Cancer BiologyNature CommunicationsPeer-reviewed
Beta cells are essential drivers of pancreatic ductal adenocarcinoma development
Cathy C. Garcia, Aarthi Venkat, Daniel C. McQuaid…·Mandar Deepak Muzumdar
This study shows that beta cells drive pancreatic ductal adenocarcinoma development through endocrine-exocrine signaling, with obesity enhancing this process via CCK+ beta cell adaptation.