Mandar Deepak Muzumdar

This study shows that diet-induced changes in phospholipid composition affect ferroptosis sensitivity and tumorigenesis in pancreatic cancer.

The paper examines the molecular effects of seven KRAS mutant variants in pancreatic cancer cells and finds that baseline cellular state, not allele identity, primarily drives molecular variation.

This study shows that beta cells drive pancreatic ductal adenocarcinoma development through endocrine-exocrine signaling, with obesity enhancing this process via CCK+ beta cell adaptation.

This study shows PI3K promotes resistance to KRAS inhibition in PDAC by activating wild-type RAS signaling through GAB1 recruitment and MAPK activation.