Culture Positivity Reflects Quantitative Bacterial Bioburden in Open Fractures
Emily Ann McClure, Roman M. Natoli, Renan C. Castillo, Anthony R. Carlini, Joseph C. Wenke, Robert V. O’Toole, Gregory M. Schrank, William Todd Obremskey, Stephen Warner, Michael J. Bosse, Benjamin D. Ross, Ida Leah Gitajn, METRC
This study shows that culture positivity in open fractures correlates with higher bacterial bioburden, suggesting microbial load rather than specific pathogens drives infection risk.
bioRxiv · Sep 23, 2026 · PreprintMicrobiology