Chronic Cochlear Implantation with and without Electric Stimulation in a Mouse Model Induces Robust Cochlear Influx of CX3CR1+/GFP Macrophages.
Alexander D. Claussen, René Vielman Quevedo, Jonathon R. Kirk, Timon Higgins, Brian J. Mostaert, Muhammad Taifur Rahman, Jacob Oleson, Reyna Hernandez, Keiko Hirose, Marlan Rex Hansen
This study shows chronic cochlear implantation, not electric stimulation, drives macrophage infiltration and fibrosis in mice, with surgical trauma initiating the immune response.
Hearing Research · Apr 25, 2022Peer-reviewedNeuroscience