Mechanophenotype of synovial fibroblasts correlates with patients' pathotypes and treatment response in Rheumatoid Arthritis
Florencia Diaz, Teresa Debatin, Lena Messner, Celia Mouchel dit Grainville, Jorge Andres, Florian Riethmüller, Ria Vaishampayan Vikrant, Raffaele Fronza, Fereydoon Taheri, Zhe Wang, Christine Selhuber‐Unkel, Federico Colombo
The paper identifies 'soft' and 'stiff' fibroblast states in rheumatoid arthritis using mechanophenotyping and transcriptomics, linking them to patient pathotypes and treatment response.
bioRxiv · Oct 6, 2026 · PreprintBiophysics