A Scalable, Open-Source Implementation of a Large-Scale Mechanistic Model for Single Cell Proliferation and Death Signaling
Cemal Erdem, Arnab Mutsuddy, Ethan M. Bensman, William B. Dodd, Michael Saint-Antoine, Mehdi Bouhaddou, Robert C. Blake, Sean M. Gross, Laura M. Heiser, F. Alex Feltus, Marc R. Birtwistle
The paper develops an open-source, scalable mechanistic model for single-cell proliferation and death signaling, demonstrating its application to understand IFNγ's anti-proliferative effects.
Nature Communications · Jun 21, 2022Peer-reviewedSystems Biology