Xenoglycosylation of the HIV-1 Glycan Shield Promotes Cross-Clade Neutralization and Diverse Human Antibody Lineages
Linling He, Xiaohe Lin, Yi-Nan Zhang, Maddy L. Newby, Connor DesRoberts, Joel D. Allen, Robyn D Stanfield, Max Crispin, Ian A. Wilson, Jiang Zhu
This study shows that xenoglycosylation of HIV-1 Env with core (1,3)-fucose enhances cross-clade neutralization and diversifies human antibody lineages.
bioRxiv · Oct 15, 2026 · PreprintImmunology