Aurora kinase A enables collective invasion and metastasis by endowing a leader cell phenotype and stabilizing cohesion with follower cells
Bo Peng Zhou, Tony LH Chu, Aidan K. Gallant, Ryan Ghorayeb, Shanshan Wang, Tariq A. Bhat, Chelsey Lynn Gough, Roderic Espín Garcia, Miguel Angel Pujana, C. James Lim, Christopher A. Maxwell
This study identifies Aurora kinase A's role in promoting collective cell invasion and metastasis by enabling leader cell phenotypes and stabilizing cohesion with follower cells.
bioRxiv · Oct 21, 2026 · PreprintCancer Biology