Machine Learning-Based Prediction of Cell-type Resolved Brain eQTLs Enhances Discovery of Variants Explaining Alzheimer's Disease Heritability
Chirag M. Lakhani, Giacomo Cavalca, Anjing Liu, Rohan Nidumbur, Ru Feng, Towfique Raj, Philip L. De Jager, Gao T. Wang, David A. Knowles
The paper develops scEEMS models to predict cell-type-specific eQTLs, enhancing discovery of AD risk variants by linking them to cell-type-specific genes.
medRxiv · Dec 4, 2025 · PreprintGenetic & Genomic Medicine