Anjing Liu

The paper presents an xQTL atlas of regulatory variation in the aging human brain, integrating multiple modalities and cell types across four studies, identifying more variant-molecular-trait associations by including TAD boundaries.

This study identifies K61-mediated K48 ubiquitination and proteasome degradation of porcine STING as a species-specific mechanism regulating antiviral signaling.

The paper develops scEEMS models to predict cell-type-specific eQTLs, enhancing discovery of AD risk variants by linking them to cell-type-specific genes.

mfSuSiE improves fine-mapping of chromatin accessibility QTLs across multiple cell types and integrates multi-omic data in aging human brain samples.

This paper links molecular mechanisms to Alzheimer's disease and aging by integrating neuroimaging endophenotypes with molecular quantitative trait loci.

fSuSiE improves fine-mapping of QTLs by modeling spatial genetic effects on molecular traits, achieving higher resolution in identifying causal variants and their molecular targets.