CD47 promotes MAPK and epithelial-to-mesenchymal transition molecular programs to drive pro-metastatic phenotypes in non-small cell lung cancer
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola Saleeb, Heyu Ni, Kelsie L. Thu
This study identifies CD47's role in promoting MAPK and EMT pathways to drive metastasis in NSCLC through cell-intrinsic signaling, independent of immune evasion.
bioRxiv · Sep 25, 2025 · PreprintCancer Biology