Author

Kelsie L. Thu

St. Michael's HospitalORCID 0000-0001-9262-7238Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Abraam Zakhary· 1 shared Asa P. Y. LauiD· 1 shared Asa P.Y. Lau· 1 shared Benjamin Haibe‐KainsiD· 1 shared David W. CesconiD· 1 shared Heyu Ni· 1 shared Jennifer SilvesteriD· 1 shared Kristyna A. Gorospe· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

Abraam Zakhary

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 28, 2026

Upregulation of PD-L1 as a putative mechanism of resistance to CD47 inhibition in non-small cell lung cancer

Asa P. Y. Lau, Kristyna A. Gorospe, Kelsie L. Thu

This study shows that PD-L1 upregulation mediates resistance to CD47 inhibition in lung cancer, and dual inhibition of CD47 and PD-L1 improves survival in mouse models.

DOI 10.64898/2026.04.24.720733

mouseexperimental assay

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Cancer BiologybioRxivPreprintSep 25, 2025

CD47 promotes MAPK and epithelial-to-mesenchymal transition molecular programs to drive pro-metastatic phenotypes in non-small cell lung cancer

Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi…·Kelsie L. Thu

This study identifies CD47's role in promoting MAPK and EMT pathways to drive metastasis in NSCLC through cell-intrinsic signaling, independent of immune evasion.

2 citations

humanbulk RNA-seq

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BioinformaticsNature CommunicationsPeer-reviewedOct 18, 2017

Gene isoforms as expression-based biomarkers predictive of drug response in vitro

Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu…·Benjamin Haibe‐Kains

The paper identifies gene isoform-based biomarkers predictive of drug response in breast cancer using pharmacogenomic data from CCLE and GDSC.

63 citations

humanbulk RNA-seq

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