Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age
Nikolay A Ivanov, Ran Tao, Joshua G Chenoweth, Anna Brandtjen, Michelle I Mighdoll, John D Genova, Ronald D McKay, Yankai Jia, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyde, Andrew E Jaffe
The paper identifies epigenetic memory in cultured human fibroblasts related to their origin and donor age, showing widespread DNA methylation and transcriptome differences.
PLOS Genetics · Feb 25, 2016Peer-reviewedCell Biology