Structure of γ-secretase (PSEN1/APH-1B) in complex with Aβ46 provides insights into amyloid-β processing and modulation by the APH-1B isoform
Ivica Odorčić, Mohamed Belal Hamed, Sam Lismont, Lucía Chávez-Gutiérrez, Rouslan G Efremov
The paper reports cryo-EM structures of γ-secretase complexes with and without Aβ46, revealing structural insights into Aβ processing and APH-1B's role.
心身医学 · May 27, 2024Peer-reviewedMolecular Biology