Rerouting of an Esx substrate pair from the ESX-1 type VII secretion system to ESX-5 by modifying a PE/PPE substrate pair
Merel P.M. Damen, Trang H. Phan, Roy Ummels, Alba Rubio-Canalejas, Wilbert Bitter, Edith N. G. Houben
The paper shows that PE35/PPE68_1 determines the secretion pathway of EsxB_1/EsxA_1 by redirecting it from ESX-1 to ESX-5 when modified with the EspG5 chaperone binding domain.
Journal of Biological Chemistry · Mar 17, 2020Peer-reviewedMolecular Biology