Mutagenic and carcinogenic potency determinations for NDMA support the cumulative dose assumption underpinning the less-than-lifetime Threshold of Toxicological Concern
John W. Wills, Angela T. White, Danielle S G Harte, Ruby A Buckley, James S Harvey, Anthony M. Lynch
The paper applies BMD modeling to NDMA datasets to support the cumulative dose assumption in the LTL-TTC framework, showing short-term assays can predict long-term carcinogenicity.
Archives of Toxicology · Apr 14, 2026Peer-reviewedPharmacology & Toxicology