John W. Wills

Mutagenic and carcinogenic potency determinations for NDMA support the cumulative dose assumption underpinning the less-than-lifetime Threshold of Toxicological Concern

The paper applies BMD modeling to NDMA datasets to support the cumulative dose assumption in the LTL-TTC framework, showing short-term assays can predict long-term carcinogenicity.

Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis

This study aligns Duplex Sequencing with transgenic rodent mutation assay data to assess in vivo NDMA-induced mutagenesis, finding dose-dependent mutation frequency increases and concordant benchmark dose estimates.

Immunocompetent Cell Targeting by Food-Additive Titanium Dioxide

This study identifies immunocompetent cells that accumulate food-grade titanium dioxide in vivo and demonstrates a mouse model for assessing human-relevant risks of ingested nanoparticles.

OPTIMAL: An OPTimsed Imaging Mass cytometry AnaLysis framework for benchmarking segmentation and data exploration

OPTIMAL benchmarks segmentation and analysis methods for Imaging Mass Cytometry data, identifying optimal parameters for cell type identification and spatial analysis.

Developing mammary terminal duct lobular units have a dynamic mucosal and stromal immune microenvironment

This study examines the dynamic immune microenvironment during sheep mammary gland development, identifying distinct phases of macrophage and lymphocyte activity and tertiary lymphoid structures.