Thermodynamic principles govern evolutionary tradeoffs by regulating allostery
Yusran Abdillah Muthahari, Reza Aditama, Mary Providaki, Alexandra Tsirigotaki, Chara Sarafoglou, Ruixue Xu, Srinath Krishnamurthy, Rukman Hertadi, Michael Kokkinidis, Cang Hui, Paola Laurino, Charalambos Pozidis, Giorgos Gouridis
The paper reveals how thermodynamic principles shape the biophysical properties of proteins through allosteric regulation and evolutionary tradeoffs.
bioRxiv · Oct 8, 2025 · PreprintBiophysics