Author

Srinath Krishnamurthy

Rega Institute for Medical ResearchORCID 0000-0001-5492-4450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Alexander I.H. SiddiquiiD· 1 shared Alexandra TsirigotakiiD· 1 shared Anastassios EconomouiD· 1 shared Bindu Y. SrinivasuiD· 1 shared Cang HuiiD· 1 shared Chara SarafoglouiD· 1 shared Charalambos PozidisiD· 1 shared Charlotte DeaneiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiophysics

Alexander I.H. SiddiquiORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintMar 4, 2026

A framework for testing structural hypotheses of protein dynamics against experimental HDX-MS data

Alexander I.H. Siddiqui, R. Skyner, Maria Musgaard…·Oliver M. Crook

The paper introduces ValDX, a framework to validate and quantify uncertainty in HDX-MS data integration with protein structural ensembles, showing it outperforms conventional metrics in distinguishing correct from incorrect models.

DOI 10.64898/2026.03.02.709114

proteomicsstatistical model

𝕏 PostBluesky

BiophysicsbioRxivPreprintOct 8, 2025

Thermodynamic principles govern evolutionary tradeoffs by regulating allostery

Yusran Abdillah Muthahari, Reza Aditama, Mary Providaki…·Giorgos Gouridis

The paper reveals how thermodynamic principles shape the biophysical properties of proteins through allosteric regulation and evolutionary tradeoffs.

1 citation

statistical modelbiophysical modeling

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BioinformaticsAnalytical ChemistryPeer-reviewedSep 15, 2021

Probing universal protein dynamics using residue-level Gibbs free energy

Jochem H. Smit, Srinath Krishnamurthy, Bindu Y. Srinivasu…·Anastassios Economou

The paper introduces PyHDX, a tool for analyzing HDX-MS data to compute residue-level Gibbs free energy across protein conditions and homologues.

44 citations

proteomicsstatistical model

𝕏 PostBluesky